A New Explanation for Chronic Fatigue Syndrome

Sixty-seven percent of 101 patients diagnosed with Chronic Fatigue Syndrome (CFS) were found to be infected with a retrovirus called XMRV (Science, published online October 8, 2009).  One hundred percent of those with CFS who subsequently developed lymphomas or leukemias were infected with the XMRV virus. If further studies confirm this finding, doctors will soon have a test to diagnose this horrible condition and possibly a vaccine to prevent it.

More than a million Americans are seriously ill with Chronic Fatigue Syndrome, also known as Myalgic encephalomyelitis. CFS symptoms include severe weakness, exhaustion after any activity, loss of memory, and chronic recurrent infections. Patients rarely recover.

The retrovirus XMRV was first found in humans in 2006, in prostate cancer cells.  It has been shown to cause nerve damage, immune deficiency, lymphoma and leukemia in animals.

Retroviruses do not have their own DNA; they use the DNA of the host cells they invade.  Retroviruses include HIV that causes AIDS, and Human Lymphotropic Viruses that cause leukemia and lymphoma.  Just as some people infected with HIV do not develop AIDS, not everyone infected with XMRV will develop CFS.  XMRV has been found in 3.7 percent of healthy Americans tested, adding up to an estimated 10 million Americans carrying this virus.

Although not proven yet, there is every reason to believe that XMRV is spread by exposure to body fluids (saliva, blood, semen).  Having an infection with one of these retroviruses impairs your immunity so that you are more likely to become infected when exposured to any other germ.

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About dr.gabe.mirkin

A practicing physician for more than 40 years and a radio talk show host for 25, Dr. Mirkin is a graduate of Harvard University and Baylor University College of Medicine. He is one of a very few doctors board-certified in four specialties: Sports Medicine, Allergy and Immunology, Pediatrics and Pediatric Immunology.

Dr. Mirkin's latest book is The Healthy Heart Miracle, published by HarperCollins. He wrote the chapter on sports injuries for the Merck Manual (both lay and physicians' editions), the largest selling book worldwide with over one million copies in print. His daily short features on fitness have been heard on CBS Radio News stations since the 1970's. He has written 16 books including The Sportsmedicine Book, the best-selling book on the subject that has been translated into many languages. More books

Dr. Mirkin did his residency at the Massachusetts General Hospital and over the years he has served as a Teaching Fellow at Johns Hopkins Medical School, Assistant Professor at the University of Maryland, and Associate Clinical Professor in Pediatrics at the Georgetown University School of Medicine.

Dr. Mirkin has run more than forty marathons and is now a serious tandem bike rider with his wife, Diana, often doing 30-60 miles in an outing.

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